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A recent meta-analysis of mixed evidence (5 RCTs 52,183,184,185,186 and 1 cohort study 187 ) in 2,071 people with T2DM or Parkinsons disease suggested antidepressant efficacy of the GLP-1RAs exenatide and liraglutide over 2452 weeks 188
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Previous studies have shown that selective depletion of synovial macrophages during experimental OA largely reduces cartilage damage and osteophyte formation, which are two major hallmarks of OA 48
It is most commonly used in benzodiazepine overdose and reversal of anesthesia
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